Analysis of a soluble calmodulin binding protein from fava bean roots: identification of glutamate decarboxylase as a calmodulin-activated enzyme.
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چکیده
منابع مشابه
Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.
Neuromodulin (formerly designated P-57) is an abundant, neural specific, calmodulin-binding protein which exhibits higher affinity for calmodulin in the absence of free Ca2+ than in the presence of free Ca2+. In this study a series of proteolytic fragments of neuromodulin were systematically screened for calmodulin-Sepharose binding activity. A 9-amino acid fragment, designated M1-C1 and having...
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The acidic, bilobed protein calmodulin (CaM; molecular mass of 16.7 kDa) can activate some 40 distinct proteins in a calcium-dependent manner. The majority of the CaM-binding domain regions of the target proteins are basic and hydrophobic in nature, are devoid of multiple negatively charged residues, and have a propensity to form an alpha-helix. The CaM-binding domain in the C-terminal region o...
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Reversible phosphorylation of specific proteins is now widely recognized as a major mechanism for controlling a variety of cellular functions in plants as in other eukaryotes (Hanks et al., 1988; Colbran et al., 1989; Poovaiah and Reddy, 1993). The presence of various protein kinase activities in plant cells has been well documented for two decades and, in recent years, severa1 of these protein...
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15 صفحه اولStructural basis for simultaneous binding of two carboxy-terminal peptides of plant glutamate decarboxylase to calmodulin.
Activation of glutamate decarboxylase (GAD) by calcium-bound calmodulin (CaM) is required for normal plant growth through regulation of gamma-aminobutyrate and glutamate metabolism. The interaction of CaM with the C-terminal domain of GAD is believed to induce dimerization of the enzyme, an event implicated for Ca(2+)-dependent enzyme activation. Here, we present the solution structure of CaM i...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 1994
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.6.8.1135